Full publication list for DuLuLabs, Juan Du, and Wei Lü
$: co-first authors; #: co-corresponding authors
Selected publications
Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution
Huang Y, Kumar S, Lee J, Lü W#, Du J# (2024) Nature Structural & Molecular Biology 31:1509–1521.
Physiological temperature drives TRPM4 ligand recognition and gating
Hu J, Park SJ, Walter T, Orozco I, O’Dea G, Ye X, Du J#, Lü W# (2024) Nature 630:509–515.
Molecular interplay of an assembly machinery for nitrous oxide reductase
Müller C$, Zhang L$, Zipfel S, Topitsch A, Lutz M, Eckert J, Prasser B, Chami M, Lü W, Du J#, Einsle O# (2022) Nature 608:626–631.
Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition
Ruan Z$, Haley E$, Orozco IJ$, Sabat M, Myers R, Roth R, Du J#, Lü W# (2021) Nature Structural & Molecular Biology 28:604–613.
Structures and pH-sensing mechanism of the proton-activated chloride channel
Ruan Z$, Osei-Owusu J$, Du J, Qiu Z#, Lü W# (2020) Nature 588:350–354.
Structures of human pannexin 1 reveal ion pathways and mechanism of gating
Ruan Z, Orozco IJ, Du J#, Lü W# (2020) Nature 584:646–651.
The structures and gating mechanism of human calcium homeostasis modulator 2
Choi W$, Clemente N$, Sun W., Du J#, Lü W# (2019) Nature 576:163–167.
Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel
Huang Y, Roth B, Lü W#, Du J# (2019) eLife 8:e50175.
Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium
Huang Y, Winkler PA, Sun W, Lü W#, Du J# (2018) Nature 562:145–149.
Structure of the human lipid-gated cation channel TRPC3
Fan C$, Choi W$, Sun W, Du J#, Lü W# (2018) eLife 7:e36852.
Electron cryo-microscopy structure of a human TRPM4 channel
Winkler PA$, Huang Y$, Sun W$, Du J, Lü W# (2017) Nature 552:200–204.
Selected publications before independence
Mechanism of gating and partial agonist action in the glycine receptor
Yu J$, Zhu H$, Lape R, Greiner T, Du J, Lü W, Sivilotti L#, Gouaux E# (2021) Cell 184:957–968.
Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation
Lü W$, Du J$,Goehring A, Gouaux E (2017) Science 335:6331.
X-ray structures define human P2X(3) receptor gating cycle and antagonist action
Mansoor SE, Lü W, Oosterheert W, Shekhar M, Tajkhorshid E, Gouaux E (2016) Nature 538:66–71.
Glycine receptor mechanism elucidated by electron cryo-microscopy
Du J$, Lü W$, Wu S, Cheng Y, Gouaux E (2015) Nature 526:224–226.
Structures of NMDA receptor reveal subunit arrangement and pore architecture
Lee CH$, Lü W$, Michel JC, Goehring A, Du J, Song X, Gouaux E (2014) Nature 511:191–197.
Structural and functional characterization of the nitrite channel NirC from Salmonella typhimurium
Lü W, Schwarzer NJ, Du J, Gerbig-Smentek E, Andrade SL, Einsle O (2012) PNAS 109:18395–18400.
The formate channel FocA exports the products of mixed-acid fermentation
Lü W, Du J, Schwarzer NJ, Gerbig-Smentek E, Einsle O, Andrade SL (2012) PNAS 109:13245–13259.
Active-site remodeling in the bifunctional fructose-1,6-biphosphate aldolase/phosophotase
Du J$, Say RF$, Lü W, Fuchs G, Einsle O (2011) Nature 478:534–537.
pH-dependent gating in a FocA formate channel
Lü W, Du J, Wacker T, Gerbig-Smentek E, Andrade SL, Einsle O (2010) Science 332:352–354.