We study the molecular mechanisms underlying chemosensation and temperature sensation.
Lab News
- Our new publication identifies TRPM4 as the target of a widely used laxative
Published today in Nature Communications: the laxative bisacodyl and its active metabolite directly activate TRPM4 to regulate intestinal fluid homeostasis. A great collaboration with Dr. Cao’s lab at China Pharmaceutical University!
- New year, new publication
A unified allosteric site controls TRPM5 function, published today in Nature Chemical Biology.
- Holiday dinner celebrating a productive 2025
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Latest Papers
Noncanonical calcium-independent TRPM4 activation governs intestinal fluid homeostasis
Liu Y, Hu J, Xue C, Huang W, Ievleva S, Lü W#, Du J#, Cao Z# (2026) Nature Communications.
A single allosteric site merges activation, modulation and inhibition in TRPM5
Ruan Z, Lee J, Li Y, Orozco I, Du J#, Lü W# (2026) Nature Chemical Biology.
Structural basis of PANX1 permeation and positive modulation by mefloquine
Li Y$, Ruan Z$, Lee J, Orozco I, Zhou E, Du J#, Lü W# (2025) Nature Communications 16:11057.