We study the molecular mechanisms underlying chemosensation and temperature sensation.


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Latest Papers

Human pannexin 1 channel is not phosphorylated by Src tyrosine kinase at Tyr199 and Tyr309
Ruan Z, Lee J, Li Y, Du J#, Lü W# (2024) eLife 13:RP95118.

Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution
Huang Y, Kumar S, Lee J, Lü W#, Du J# (2024) Nature Structural & Molecular Biology 31:1509–1521.

Physiological temperature drives TRPM4 ligand recognition and gating
Hu J, Park SJ, Walter T, Orozco I, O’Dea G, Ye X, Du J#Lü W# (2024) Nature 630:509–515.

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