We study the molecular mechanisms underlying chemosensation and temperature sensation.
Lab News
- Our CNNM4 Study Published in Cell
The CNNM4 magnesium transporter is a dimer of asymmetric dimers.
Congratulations to Zhiyong and Edward!
- Jinhong Receives Second AHA Postdoctoral Fellowship
Congratulations to Jinhong on receiving a second two-year American Heart Association (AHA) Postdoctoral Fellowship! Jinhong also recently presented his TRPM4 work at the Ion Channels Gordon Research Seminar (GRS) at Mount Holyoke College.
- Sophia Du and Sarah Wang Receive MBS Summer Fellowships
Sophia and Sarah, both undergraduates at Northwestern University, have been awarded summer fellowships from the Department of Molecular Biosciences. The fellowships will support eight weeks of full-time summer research in the lab. Congratulations!
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Latest Papers
Dynamic dimer-of-dimers architecture defines Mg2+ transport in human CNNM4
Bai Z, Zhou E, Lü W#, Du J# (2026) Cell.
Temperature and intrinsic Ca2+ reshape TRPM4 pharmacology
Hu J, Ievleva S, Park SJ, Lee J, Cheng J, O’Dea G, Sheng J, Du J#, Lü W# (2026) Nature Structural & Molecular Biology.
Noncanonical calcium-independent TRPM4 activation governs intestinal fluid homeostasis
Liu Y$, Hu J$, Xue C$, Huang W$, Ievleva S, Lü W#, Du J#, Cao Z# (2026) Nature Communications.
A single allosteric site merges activation, modulation and inhibition in TRPM5
Ruan Z, Lee J, Li Y, Orozco I, Du J#, Lü W# (2026) Nature Chemical Biology.