We study the molecular mechanisms underlying chemosensation and temperature sensation.
Lab News
- Jiangnan Awarded Undergraduate Research Grant
Congratulations to Jiangnan Sheng on receiving an Academic Year Undergraduate Research Grant from Northwestern University’s Office of Undergraduate Research to support research in our lab.
- New undergraduate researchers join the lab
Welcome to Stella Cui and Hana Chen! Both are second-year undergraduate students at Northwestern and recently joined the lab.
- Our CNNM4 Study Published in Cell
The CNNM4 magnesium transporter is a dimer of asymmetric dimers.
Congratulations to Zhiyong and Edward!
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Latest Papers
Dynamic dimer-of-dimers architecture defines Mg2+ transport in human CNNM4
Bai Z, Zhou E, Lü W#, Du J# (2026) Cell.
Temperature and intrinsic Ca2+ reshape TRPM4 pharmacology
Hu J, Ievleva S, Park SJ, Lee J, Cheng J, O’Dea G, Sheng J, Du J#, Lü W# (2026) Nature Structural & Molecular Biology.
Noncanonical calcium-independent TRPM4 activation governs intestinal fluid homeostasis
Liu Y$, Hu J$, Xue C$, Huang W$, Ievleva S, Lü W#, Du J#, Cao Z# (2026) Nature Communications.
A single allosteric site merges activation, modulation and inhibition in TRPM5
Ruan Z, Lee J, Li Y, Orozco I, Du J#, Lü W# (2026) Nature Chemical Biology.