Lab News

• Our preprint on how temperature and calcium reshape TRPM4 pharmacology is now published in NSMBJune 9, 2026

  

• Congratulations, Dr. Sofia Ievleva!June 4, 2026

  A proud moment from the Van Andel Institute Graduate School Commencement Ceremony on May 27, 2026.

  

• Welcome summer interns Kellie Wu and Alex LiuMay 26, 2026

  Kellie is a second-year undergraduate student pursuing a B.S. in Biochemistry at Case Western Reserve University.
  Alex has just completed his first year at University of California, Berkeley and has returned to the lab for a summer internship.

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Latest Papers

Temperature and intrinsic Ca²⁺ reshape TRPM4 pharmacology
Hu J, Ievleva S, Park SJ, Lee J, Cheng J, O’Dea G, Sheng J, Du J^#, Lü W^# (2026) Nature Structural & Molecular Biology.

Noncanonical calcium-independent TRPM4 activation governs intestinal fluid homeostasis
Liu Y^$, Hu J^$, Xue C^$, Huang W^$, Ievleva S, Lü W^#, Du J^#, Cao Z^# (2026) Nature Communications.

A single allosteric site merges activation, modulation and inhibition in TRPM5
Ruan Z, Lee J, Li Y, Orozco I, Du J^#, Lü W^# (2026) Nature Chemical Biology.

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