We study the molecular mechanisms underlying chemosensation and temperature sensation.
Lab News
- Congratulations, Dr. Sofia Ievleva!
A proud moment from the Van Andel Institute Graduate School Commencement Ceremony on May 27, 2026.
- Welcome summer interns Kellie Wu and Alex Liu
Kellie is a second-year undergraduate student pursuing a B.S. in Biochemistry at Case Western Reserve University.
Alex has just completed his first year at University of California, Berkeley and has returned to the lab for a summer internship. - Sarah Awarded NIH F31 Fellowship
Congratulations to Sarah Keuning on receiving an F31 fellowship from the National Institute of Neurological Disorders and Stroke for her research on CALHM channels!
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Latest Papers
Temperature and intrinsic Ca2+ reshape TRPM4 pharmacology
Hu J, Ievleva S, Park SJ, Lee J, Cheng J, O’Dea G, Sheng J, Du J#, Lü W# (2026) bioRxiv.
Noncanonical calcium-independent TRPM4 activation governs intestinal fluid homeostasis
Liu Y$, Hu J$, Xue C$, Huang W$, Ievleva S, Lü W#, Du J#, Cao Z# (2026) Nature Communications.
A single allosteric site merges activation, modulation and inhibition in TRPM5
Ruan Z, Lee J, Li Y, Orozco I, Du J#, Lü W# (2026) Nature Chemical Biology.