Lab News

• Holiday dinner celebrating a productive 2025December 12, 2025

  

• Our paper on ATP permeation and mefloquine potentiation of PANX1 is published todayDecember 12, 2025

  After 26 months (!) from initial submission to publication, our PANX1 study is finally out in Nature Communications! The extremely long review process made this a truly memorable experience (for better or worse), and the team’s persistence and dedication carried it through.
  
  Thanks to everyone on the PANX1 team for their hard work and resilience!

• Our reviewed preprint on understudied CALHM channels is published at eLife todayNovember 18, 2025

  Through our collaboration with the Kannan lab at the University of Georgia, we reveal conserved gating determinants in understudied CALHM ion channels using an evolutionary analysis approach combined with electrophysiology.

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Latest Papers

Structural basis of PANX1 permeation and positive modulation by mefloquine
Li Y^$, Ruan Z^$, Lee J, Orozco I, Zhou E, Du J^#, Lü W^# (2025) Nature Communications 16:11057.

Identification and classification of ion-channels across the tree of life provide functional insights into understudied CALHM channels
Taujale R^$, Park SJ^$, Gravel N, Soleymani S, Carter R, Boyd K, Keuning S, Ruan Z, Lü W^#, Kannan N^# (2025) eLife 14:RP106134.

Structural basis for agonist and heat activation of nociceptor TRPM3
Kumar S^$, Jin F^$, Park SJ, Choi W, Keuning S, Massimino R, Vu S, Lü W^#, Du J^# (2025) Nature Structural & Molecular Biology.

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