$: co-first authors; #: co-corresponding authors
2021 – now
- Human pannexin 1 channel is not phosphorylated by Src tyrosine kinase at Tyr199 and Tyr309
Ruan Z, Lee J, Li Y, Du J#, Lü W# (2024) eLife 13:RP95118. - Coupling enzymatic activity and gating in an ancient TRPM chanzyme and its molecular evolution
Huang Y, Kumar S, Lee J, Lü W#, Du J# (2024) Nature Structural & Molecular Biology. - Physiological temperature drives TRPM4 ligand recognition and gating
Hu J, Park SJ, Walter T, Orozco I, O’Dea G, Ye X, Du J#, Lü W# (2024) Nature 630:509–515. - Inhibition of the proton-activated chloride channel PAC by PIP2
Mihaljević L$, Ruan Z$, Osei-Owusu J, Lü W#, Qiu Z# (2023) eLife 12:e83935. - Molecular mechanism underlying desensitization of the proton-activated chloride channel PAC
Osei-Owusu J$, Ruan Z$, Mihaljević L, Matasic D, Chen KH, Lü W#, Qiu Z# (2022) eLife 11:e82955. - Molecular interplay of an assembly machinery for nitrous oxide reductase
Müller C$, Zhang L$, Zipfel S, Topitsch A, Lutz M, Eckert J, Prasser B, Chami M, Lü W, Du J#, Einsle O# (2022) Nature 608:626–631. - Molecular determinants of pH sensing in the proton-activated chloride channel
Osei-Owusu J, Kots E, Ruan Z, Mihaljević L, Chen KH, Tamhaney A, Ye X, Lü W, Weinstein H, Qiu Z (2022) PNAS 119(31):e2200727119. - Structures of the TRPM5 channel elucidate mechanisms of activation and inhibition
Ruan Z$, Haley E$, Orozco IJ$, Sabat M, Myers R, Roth R, Du J#, Lü W# (2021) Nature Structural & Molecular Biology 28:604–613. - Mechanism of gating and partial agonist action in the glycine receptor
Yu J$, Zhu H$, Lape R, Greiner T, Du J, Lü W, Sivilotti L#, Gouaux E# (2021) Cell 184:957–968. - Proton-activated chloride channel PAC regulates endosomal acidification and transferrin receptor-mediated endocytosis
Osei-Owusu J, Yang J, Leung KH, Ruan Z, Lü W, Krishnan Y, Qiu Z (2021) Cell reports 34(4):108683.
2016 – 2020
- Structures and pH-sensing mechanism of the proton-activated chloride channel
Ruan Z$, Osei-Owusu J$, Du J, Qiu Z#, Lü W# (2020) Nature 588:350–354. - Structures of human pannexin 1 reveal ion pathways and mechanism of gating
Ruan Z, Orozco IJ, Du J#, Lü W# (2020) Nature 584:646–651. - The N-terminal domain in TRPM2 channel is a conserved nucleotide binding site
Lü W, Du J (2020) Journal of General Physiology 152(5). - A structural overview of the ion channels of the TRPM family
Huang Y, Fliegert R, Guse AH, Lü W#, Du J# (2020) Cell Calcium 85:102111. - The structures and gating mechanism of human calcium homeostasis modulator 2
Choi W$, Clemente N$, Sun W., Du J#, Lü W# (2019) Nature 576:163–167. - Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel
Huang Y, Roth B, Lü W#, Du J# (2019) eLife 8:e50175. - Expression and purification of the human lipid-sensitive cation channel TRPC3 for structural determination by single-particle cryo-electron microscopy
Haley E$, Choi W$, Fan C, Sun W, Du J, Lü W (2019) JoVE 7(143):e58754. - Architecture of the TRPM2 channel and its activation mechanism by ADP-ribose and calcium
Huang Y, Winkler PA, Sun W, Lü W#, Du J# (2018) Nature 562:145–149. - Structure of the human lipid-gated cation channel TRPC3
Fan C$, Choi W$, Sun W, Du J#, Lü W# (2018) eLife 7:e36852. - Electron cryo-microscopy structure of a human TRPM4 channel
Winkler PA$, Huang Y$, Sun W$, Du J, Lü W# (2017) Nature 552:200–204. - Cryo-EM structures of the triheteromeric NMDA receptor and its allosteric modulation
Lü W$, Du J$,Goehring A, Gouaux E (2017) Science 335:6331. - X-ray structures define human P2X(3) receptor gating cycle and antagonist action
Mansoor SE, Lü W, Oosterheert W, Shekhar M, Tajkhorshid E, Gouaux E (2016) Nature 538:66–71.
2010 – 2015
- Glycine receptor mechanism elucidated by electron cryo-microscopy
Du J$, Lü W$, Wu S, Cheng Y, Gouaux E (2015) Nature 526:224–226. - Structural and functional studies of NirC from Salmonella typhimurium
Rycovska-Blume A, Lü W, Andrade SL, Fendler K, Einsle O (2015) Methods in Enzymology Vol. 556, 475–497. - Structures of NMDA receptor reveal subunit arrangement and pore architecture
Lee CH$, Lü W$, Michel JC, Goehring A, Du J, Song X, Gouaux E (2014) Nature 511:191–197. - The formate/nitrite transporter family of anion channels
Lü W, Du J, Schwarzer N, Wacker T, Andrade SL, Einsle O (2013) Biological chemistry 394(6):715–27. - Structural and functional characterization of the nitrite channel NirC from Salmonella typhimurium
Lü W, Schwarzer NJ, Du J, Gerbig-Smentek E, Andrade SL, Einsle O (2012) PNAS 109:18395–18400. - The formate channel FocA exports the products of mixed-acid fermentation
Lü W, Du J, Schwarzer NJ, Gerbig-Smentek E, Einsle O, Andrade SL (2012) PNAS 109:13245–13259. - Molecular characteristics of Clostridium perfringens TpeL toxin and consequences of mono-O-GlcNAcylation of Ras in living cells
Guttenberg G, Hornei S, Jank T, Schwan C, Lü W, Einsle O, Papatheodorou P, Aktories K (2012) Journal of Biological Chemistry 287(30):24929–40 - Mechanism of Disruption of the Amt-GlnK Complex by PII-Mediated Sensing of 2-Oxoglutarate
Maier S, Schleberger P, Lü W, Wacker T, Pflüger T, Litz C, Andrade SL (2011) PLOS ONE 6(10):e26327. - Active-site remodeling in the bifunctional fructose-1,6-biphosphate aldolase/phosophotase
Du J$, Say RF$, Lü W, Fuchs G, Einsle O (2011) Nature 478:534–537. - Inositol hexakisphosphate-dependent processing of Clostridium sordellii lethal toxin and Clostridium novyi α-toxin
Guttenberg G$, Papatheodorou P$, Genisyuerek S, Lü W, Jank T, Einsle O, Aktories K (2011) Journal of Biological Chemistry 286(17):14779–14786. - pH-dependent gating in a FocA formate channel
Lü W, Du J, Wacker T, Gerbig-Smentek E, Andrade SL, Einsle O (2011) Science 332:352–354. - Cooperative binding of MgATP and MgADP in the trimeric PII protein GlnK2 from Archaeoglobus fulgidus
Helfmann S, Lü W, Litz C, Andrade SL (2010) Journal of Molecular Biology 402(1):165–177 - Structural Basis of the Action of Glucosyltransferase Lgt1 from Legionella pneumophila
Lü W, Du J, Stahl M, Tzivelekidis T, Belyi Y, Gerhardt S, Aktories K, Einsle O (2010) Journal of Molecular Biology 396(2):321–331.